During withdrawal from an upper, what is the expected physiological reaction?

During withdrawal from an upper, which typically refers to stimulants such as cocaine or amphetamines, the expected physiological reaction is that everything goes down. This is because stimulants tend to increase central nervous system activity, heart rate, and blood pressure when used. During withdrawal, the body is no longer experiencing the effects of these stimulants, leading to a rebound effect where physiological functions decrease significantly.

Symptoms can include fatigue, depression, increased appetite, and a general slowing of bodily functions. This hypostimulation can manifest in lowered energy levels and diminished alertness, making it clear that there is a significant downturn in the body's overall physiological response during withdrawal from these substances. Hence, a decrease across various physiological parameters is characteristic of this stage.