How does NPH insulin's duration compare to Humalog's?

NPH insulin, which is an intermediate-acting insulin, typically has a duration of 10 to 16 hours. It is designed to provide a baseline level of insulin, helping to cover glucose levels for an extended period throughout the day. On the other hand, Humalog, which is a rapid-acting insulin, has a much shorter duration of action, lasting approximately 3 to 5 hours. This rapid onset and quick duration make Humalog suitable for meals, as it helps control blood sugar spikes that occur after eating.

In comparing the two, NPH insulin’s longer duration is essential for maintaining blood glucose levels over several hours, especially between meals and overnight. This fundamental difference in the pharmacokinetics of NPH and Humalog is why it's understood that NPH lasts longer than Humalog.