What is a primary consideration when administering neomycin?

When administering neomycin, a primary consideration is its potential to cause significant renal toxicity. This aminoglycoside antibiotic is known for its nephrotoxic effects, particularly when used for an extended period or at high doses. Monitoring renal function through assessments of serum creatinine and urine output is essential to mitigate the risk of acute kidney injury.

Neomycin's mechanism of action and its route of administration can lead to elevated levels in the bloodstream, especially in individuals with pre-existing renal issues or those who are dehydrated, making vigilance crucial during therapy. While the other factors mentioned could be relevant in specific contexts, they do not represent the most critical concern when safely administering neomycin.