Which two drugs are noted for increasing blood sugar levels?

Glucagon and Epinephrine are both associated with increasing blood sugar levels, which makes this choice the correct answer.

Glucagon is a hormone produced by the alpha cells of the pancreas that promotes the conversion of stored glycogen into glucose in the liver, leading to an increase in blood sugar levels. This mechanism is particularly important during times of hypoglycemia, where the rapid elevation of glucose is needed to maintain homeostasis.

Epinephrine, also known as adrenaline, is a hormone released from the adrenal glands during stress or a 'fight or flight' response. It stimulates several metabolic processes, including the breakdown of glycogen to glucose, which boosts blood sugar levels to provide quick energy for the body. This catecholamine plays a key role in the physiological response to stress.

Both of these agents are important in medical situations such as treating severe hypoglycemia or in patients experiencing acute stress responses, further supporting their role in raising blood glucose levels.